Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 6/20 | 0.45 |
| ▸ | PARP11 | Q9NR21 | 6/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12495619 | 0.86 | MAPK1 (0.45) | MAP4K4MAPK1PARP10PARP11MAPKAPK2 | |
| SCHEMBL12077344 | 0.85 | MAPK1 (0.44) | MAP4K4MAPK1PARP10PARP11MAPKAPK2 | |
| SCHEMBL18936990 | 0.81 | MAPK1 (0.49) | MAP4K4MAPK1PARP10PARP11MAPKAPK2 | |
| SCHEMBL12077536 | 0.81 | MAP4K4 (0.45) | MAP4K4MAPK1PARP10PARP11MAPKAPK2 | |
| SCHEMBL18936971 | 0.81 | MAPK1 (0.60) | MAP4K4MAPK1PARP10PARP11MAPKAPK2 | |
| SCHEMBL18112900 | 0.80 | MAPK1 (0.54) | MAP4K4MAPK1PARP10PARP11MAPKAPK2 | |
| SCHEMBL18937023 | 0.79 | MAPK1 (0.49) | MAP4K4MAPK1PARP10PARP11MAPKAPK2 | |
| SCHEMBL12495062 | 0.79 | MAPKAPK2 (0.57) | MAPK1PARP10PARP11MAPKAPK2MAPK9 | |
| SCHEMBL18936993 | 0.78 | MAP4K4 (0.50) | MAP4K4MAPK1MAPKAPK2MAP4K1 | |
| SCHEMBL12495672 | 0.78 | MAPK1 (0.52) | MAP4K4MAPK1PARP10PARP11MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2681206-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012121992-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |