Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 8/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 7/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | CTSC | P53634 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18936967 | 0.86 | MAPK1 (0.42) | MAPK1MAPKAPK2PARP10PARP11MAPK9 | |
| SCHEMBL12495627 | 0.81 | MAP4K4 (0.55) | MAPK1MAPKAPK2PARP10PARP11MAPK9 | |
| SCHEMBL18112900 | 0.79 | MAPK1 (0.54) | MAPK1MAPKAPK2PARP10PARP11MAPK9 | |
| SCHEMBL12495672 | 0.77 | MAPK1 (0.52) | MAPK1MAPKAPK2PARP10PARP11MAPK9 | |
| SCHEMBL18936971 | 0.76 | MAPK1 (0.60) | MAPK1MAPKAPK2PARP10PARP11MAPK9 | |
| SCHEMBL12495062 | 0.76 | MAPKAPK2 (0.57) | MAPK1MAPKAPK2PARP10PARP11MAPK9 | |
| SCHEMBL20087312 | 0.75 | MAPK1 (0.63) | MAPK1MAPKAPK2PARP10PARP11MAPK9 | |
| SCHEMBL18113197 | 0.74 | MAPK1 (0.53) | MAPK1MAPKAPK2PARP10PARP11GSK3B | |
| SCHEMBL18112990 | 0.74 | MAPK1 (0.52) | MAPK1MAPKAPK2PARP10PARP11GSK3B | |
| SCHEMBL18112955 | 0.74 | MAPK1 (0.52) | MAPK1MAPKAPK2PARP10PARP11MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |