Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.42 |
| ▸ | ATR | Q13535 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.38 |
| ▸ | DCK | P27707 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18936946 | 0.91 | MAPK1 (0.48) | KCNH2PIK3CGPIK3CAATRPIK3CD | |
| SCHEMBL12495772 | 0.86 | KCNH2 (0.45) | KCNH2PIK3CGPIK3CAATRPIK3CD | |
| SCHEMBL12496015 | 0.84 | GSK3B (0.44) | KCNH2PIK3CGPIK3CAATRPIK3CD | |
| SCHEMBL12495789 | 0.83 | KCNH2 (0.39) | KCNH2ATRALOX5APFEN1MAPK1 | |
| SCHEMBL12078097 | 0.82 | ATR (0.40) | KCNH2ATRMAPK1 | |
| SCHEMBL18936948 | 0.81 | PIK3CG (0.43) | KCNH2PIK3CGPIK3CAATRPIK3CD | |
| SCHEMBL12496252 | 0.81 | KCNH2 (0.44) | KCNH2PIK3CGPIK3CAATRPIK3CD | |
| SCHEMBL12077884 | 0.81 | KCNH2 (0.44) | KCNH2PIK3CGPIK3CAATRPIK3CD | |
| SCHEMBL12495701 | 0.79 | KCNH2 (0.46) | KCNH2PIK3CGPIK3CAATRPIK3CD | |
| SCHEMBL12078764 | 0.79 | PIK3CG (0.44) | KCNH2PIK3CGPIK3CAATRPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2681206-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012121992-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |