Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 10/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.40 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12496252 | 0.90 | KCNH2 (0.44) | PIK3CGPIK3CAKCNH2PIK3CDPIK3R2 | |
| SCHEMBL18937000 | 0.88 | PIK3CG (0.42) | PIK3CGPIK3CAKCNH2PIK3CDPIK3R2 | |
| SCHEMBL18937024 | 0.87 | KCNH2 (0.56) | PIK3CGKCNH2PIK3CDPIK3CBPIK3C3 | |
| SCHEMBL12078764 | 0.86 | PIK3CG (0.44) | PIK3CGPIK3CAKCNH2PIK3CDPIK3R2 | |
| SCHEMBL12495701 | 0.84 | KCNH2 (0.46) | PIK3CGPIK3CAKCNH2PIK3CDPIK3R2 | |
| SCHEMBL18936981 | 0.84 | KCNH2 (0.39) | KCNH2ALOX5APFEN1ATRPRKDC | |
| SCHEMBL12495772 | 0.84 | KCNH2 (0.45) | PIK3CGPIK3CAKCNH2PIK3CDPIK3R2 | |
| SCHEMBL12495821 | 0.83 | KCNH2 (0.45) | PIK3CGPIK3CAKCNH2PIK3CDPIK3R2 | |
| SCHEMBL18936946 | 0.83 | MAPK1 (0.48) | PIK3CGPIK3CAKCNH2PIK3CDPIK3R2 | |
| SCHEMBL18937005 | 0.82 | NOS1 (0.38) | KCNH2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |