Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 6/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 3/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.31 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12495641 | 0.94 | MAP4K4 (0.36) | MAP4K4ATRCDC7CHEK1KCNH2 | |
| SCHEMBL12077563 | 0.90 | MAP4K4 (0.39) | MAP4K4ATRCDC7CHEK1FGFR1 | |
| SCHEMBL12495768 | 0.84 | MAP4K4 (0.40) | MAP4K4ATRCHEK1FGFR1FGFR4 | |
| SCHEMBL12077344 | 0.83 | MAPK1 (0.44) | MAP4K4ATR | |
| SCHEMBL12077536 | 0.80 | MAP4K4 (0.45) | MAP4K4 | |
| SCHEMBL12495807 | 0.80 | MAP4K4 (0.49) | MAP4K4CDC7MAP4K1KCNH2 | |
| SCHEMBL12495678 | 0.79 | MAP4K4 (0.38) | MAP4K4ATRCHEK1KCNH2ALOX5AP | |
| SCHEMBL12076937 | 0.79 | MAP4K4 (0.38) | MAP4K4ATRCHEK1KCNH2ALOX5AP | |
| SCHEMBL18937023 | 0.78 | MAPK1 (0.49) | MAP4K4ATRCHEK1 | |
| SCHEMBL18937027 | 0.77 | ATR (0.45) | MAP4K4ATRFGFR1FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |
| EP-2681206-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | Lexicon Pharmaceuticals, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012121992-A1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |