Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 9/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.34 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077563 | 0.88 | MAP4K4 (0.39) | ATRMAPKAPK2ALOX5APFEN1MAP4K4 | |
| SCHEMBL18937005 | 0.87 | NOS1 (0.38) | ATRMAPKAPK2KCNH2 | |
| SCHEMBL12495603 | 0.82 | MAPK1 (0.48) | ATRMAPKAPK2 | |
| SCHEMBL18936948 | 0.80 | PIK3CG (0.43) | ATRALOX5APFEN1KCNH2 | |
| SCHEMBL18936981 | 0.78 | KCNH2 (0.39) | ATRALOX5APFEN1KCNH2 | |
| SCHEMBL12495990 | 0.77 | MAP4K4 (0.39) | ATRALOX5APFEN1MAP4K4FGFR1 | |
| SCHEMBL18936996 | 0.75 | ATR (0.47) | ATRMAPKAPK2MAP4K4FGFR1FGFR2 | |
| SCHEMBL12495641 | 0.74 | MAP4K4 (0.36) | ATRMAPKAPK2ALOX5APFEN1MAP4K4 | |
| SCHEMBL12090677 | 0.74 | TYRO3 (0.34) | ATRMAPKAPK2ALOX5APFEN1KCNH2 | |
| SCHEMBL18937000 | 0.74 | PIK3CG (0.42) | ALOX5APFEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681206-B1 | MST1 KINASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2017-06-14 | — | — | EP | disclosed |