Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.35 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695107 | 0.85 | HTR1D (0.42) | JAK3CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL3730728 | 0.69 | AKT2 (0.39) | JAK3JAK2JAK1TYK2HPGDS | |
| Hydrochloric Acid SCHEMBL3716590 | 0.68 | AKT2 (0.39) | JAK3JAK2JAK1TYK2HPGDS | |
| SCHEMBL3739352 | 0.68 | JAK1 (0.44) | JAK3JAK2JAK1TYK2TSHR | |
| SCHEMBL4340262 | 0.67 | PDE4B (0.54) | JAK3CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL15007485 | 0.66 | RPS6KA3 (0.44) | JAK3CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL285566 | 0.66 | CCNE2 (0.42) | CCNE1CDK2CCNE2CCNB2CDK1 | |
| SCHEMBL17105468 | 0.65 | HCAR2 (0.35) | HCAR2CAMKK2SMN1; SMN2 | |
| SCHEMBL21157774 | 0.64 | CDK2 (0.46) | JAK3CCNE1CDK2CCNE2CCNB2 | |
| SCHEMBL22018238 | 0.64 | CDK2 (0.46) | JAK3CCNE1CDK2CCNE2CCNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681216-A2 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2014-01-08 | — | — | EP | disclosed |
| WO-2012118812-A2 | SUBSTITUTED 6,5-FUSED BICYCLIC HETEROARYL COMPOUNDS | Epizyme, Inc. (US) | 2012-09-07 | — | — | WO | disclosed |