Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 7/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.42 |
| ▸ | CDK2 | P24941 | 7/20 | 0.42 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 3/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285150 | 0.79 | MAPK1 (0.40) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL9937393 | 0.76 | PRKCQ (0.43) | MAPK1LMNAMAPTCSF1RALDH1A1 | |
| SCHEMBL15007485 | 0.69 | RPS6KA3 (0.44) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL285235 | 0.66 | CCNE2 (0.40) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL12499752 | 0.66 | JAK3 (0.43) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL1694708 | 0.64 | KDM4E (0.44) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL2112360 | 0.64 | CCNE2 (0.46) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL29705507 | 0.64 | KDM4E (0.44) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL5261917 | 0.64 | CCNE2 (0.66) | CCNE2CCNE1CDK2CCNB2CDK1 | |
| SCHEMBL25413337 | 0.63 | ALDH1A1 (0.39) | CCNE2CCNE1CDK2CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427464-A1 | PYRAZOLOPYRIDINES | Vertex Pharmaceuticals Incorporated (US) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010129668-A1 | PYRAZOLOPYRIDINES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-11-11 | — | — | WO | disclosed |