Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.42 |
| ▸ | MLNR | O43193 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5059571 | 0.82 | MLNR (0.56) | SIGMAR1HRH3HRH4MLNRCYP3A4 | |
| SCHEMBL3396312 | 0.82 | LMNA (0.51) | SIGMAR1HRH3ALDH1A1HRH4MLNR | |
| SCHEMBL3396309 | 0.82 | LMNA (0.51) | SIGMAR1HRH3ALDH1A1HRH4MLNR | |
| SCHEMBL5059568 | 0.82 | MLNR (0.56) | SIGMAR1HRH3HRH4MLNRCYP3A4 | |
| SCHEMBL3324661 | 0.81 | FUCA1 (0.55) | SIGMAR1ALDH1A1MLNRCYP3A4ACHE | |
| SCHEMBL4279682 | 0.81 | FUCA1 (0.55) | SIGMAR1ALDH1A1MLNRCYP3A4ACHE | |
| SCHEMBL3522692 | 0.81 | FUCA1 (0.55) | SIGMAR1ALDH1A1MLNRCYP3A4ACHE | |
| SCHEMBL3522693 | 0.81 | FUCA1 (0.55) | SIGMAR1ALDH1A1MLNRCYP3A4ACHE | |
| SCHEMBL1427573 | 0.80 | HRH3 (0.73) | HRH3KDM4EALDH1A1HRH4RORC | |
| SCHEMBL1896032 | 0.80 | HRH3 (0.73) | HRH3KDM4EALDH1A1HRH4RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012048411-A1 | PLK-4 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2012-04-19 | — | — | WO | disclosed |
| WO-2012048411-A1 | PLK-4 INHIBITORS AND METHOD OF TREATING CANCER WITH SAME | UNIVERSITY HEALTH NETWORK (CA) | 2012-04-19 | — | — | WO | disclosed |