Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501421 | 0.90 | L3MBTL1 (0.50) | L3MBTL1MAPTTHRBKDM4EALDH1A1 | |
| SCHEMBL16175487 | 0.88 | MAPT (0.56) | L3MBTL1MAPTTHRBKDM4EHSD17B10 | |
| SCHEMBL3061254 | 0.77 | L3MBTL1 (0.70) | L3MBTL1MAPTTHRBKDM4EALDH1A1 | |
| SCHEMBL7877590 | 0.76 | L3MBTL1 (0.72) | L3MBTL1MAPTTHRBKDM4EALDH1A1 | |
| SCHEMBL5426590 | 0.76 | L3MBTL1 (1.00) | L3MBTL1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL18067891 | 0.76 | L3MBTL1 (0.72) | L3MBTL1MAPTTHRBKDM4EALDH1A1 | |
| SCHEMBL20559065 | 0.75 | L3MBTL1 (0.70) | L3MBTL1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL1096760 | 0.75 | L3MBTL1 (0.70) | L3MBTL1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL4919697 | 0.75 | L3MBTL1 (0.70) | L3MBTL1MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL14253162 | 0.74 | L3MBTL1 (0.51) | L3MBTL1MAPTTHRBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668177-B1 | SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-10-22 | — | — | EP | disclosed |
| EP-2668177-A1 | SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101013-A1 | SUBSTITUTED PYRIDINYL-PYRIMIDINES AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-08-02 | — | — | WO | disclosed |