Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 11/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22792321 | 0.83 | CCNT1 (0.38) | CCNT1CDK9IRAK1CLK1CLK2 | |
| SCHEMBL1192676 | 0.83 | CCNT1 (0.55) | CCNT1CDK9KDR | |
| SCHEMBL1326639 | 0.81 | CCNT1 (0.43) | CCNT1KDR | |
| SCHEMBL9950150 | 0.78 | CCNT1 (0.57) | CCNT1CDK9 | |
| SCHEMBL12501725 | 0.78 | CCNT1 (0.58) | CCNT1CDK9SCN5A | |
| SCHEMBL22792023 | 0.75 | CCNT1 (0.42) | CCNT1CDK9IRAK1PDCD1CD274 | |
| SCHEMBL12898139 | 0.74 | CCNT1 (0.68) | CCNT1 | |
| SCHEMBL12898181 | 0.74 | CCNT1 (0.68) | CCNT1 | |
| SCHEMBL12898179 | 0.74 | CCNT1 (0.68) | CCNT1 | |
| SCHEMBL9950146 | 0.74 | CCNT1 (0.54) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012101064-A1 | N-ACYL PYRIMIDINE BIARYL COMPOUNDS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |