Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 9/20 | 0.73 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.73 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.73 |
| ▸ | CDK1 | P06493 | 7/20 | 0.73 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.73 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.73 |
| ▸ | CDK4 | P11802 | 3/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.73 |
| ▸ | CHEK1 | O14757 | 9/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.48 |
| ▸ | RAF1 | P04049 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.46 |
| ▸ | PRKCG | P05129 | 3/20 | 0.46 |
| ▸ | PRKCB | P05771 | 3/20 | 0.46 |
| ▸ | PRKCA | P17252 | 3/20 | 0.46 |
| ▸ | PRKCH | P24723 | 3/20 | 0.46 |
| ▸ | PRKCI | P41743 | 3/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1250325 | 1.00 | CDK5 (0.73) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL17166885 | 0.81 | CDK5 (0.57) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL15426067 | 0.80 | CDK5 (0.73) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Debromohymenialdisine SCHEMBL4303192 | 0.77 | CDK5 (0.70) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Debromohymenialdisine SCHEMBL3578000 | 0.77 | CDK5 (0.70) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Debromohymenialdisine SCHEMBL3577997 | 0.77 | CDK5 (0.70) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Hymenialdisine SCHEMBL155899 | 0.77 | CHEK2 (0.74) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Hymenialdisine SCHEMBL1249686 | 0.77 | CHEK2 (0.74) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| Hymenialdisine SCHEMBL1249687 | 0.77 | CHEK2 (0.74) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL3426076 | 0.75 | CDK5 (0.46) | CDK5CDK5R1CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312390-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2009-12-17 | — | — | US | claimed |
| US-20040186159-A1 | Inhibitors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma | NOVARTIS AG (CH) | 2004-09-23 | — | — | US | claimed |
| EP-2281560-A1 | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucomatous optic neuropathy | Alcon, Inc. (CH) | 2011-02-09 | — | — | EP | disclosed |
| US-20090312390-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2009-12-17 | — | — | US | disclosed |
| US-7598288-B2 | Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma | ALCON, INC. (CH) | 2009-10-06 | — | — | US | disclosed |
| US-20040186159-A1 | Inhibitors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma | NOVARTIS AG (CH) | 2004-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040186159-A1 | Inhibitors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma | GSK3B, GSK3A, GSKIP | CDK5 367/4885CDK5R1 778/4885CCNB2 3391/4885 |
| US-20090312390-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA | GSK3B, GSK3A, GSKIP | CDK5 367/4885CDK5R1 778/4885CCNB2 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.