Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.70 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.70 |
| ▸ | CHEK1 | O14757 | 8/20 | 0.70 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.70 |
| ▸ | CDK1 | P06493 | 7/20 | 0.70 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.70 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.70 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.70 |
| ▸ | RAF1 | P04049 | 3/20 | 0.70 |
| ▸ | PRKCB | P05771 | 4/20 | 0.61 |
| ▸ | PRKCA | P17252 | 4/20 | 0.61 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.61 |
| ▸ | PRKCG | P05129 | 3/20 | 0.61 |
| ▸ | PRKCH | P24723 | 3/20 | 0.61 |
| ▸ | PRKCI | P41743 | 3/20 | 0.61 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.61 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.61 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Debromohymenialdisine SCHEMBL3577997 | 1.00 | CDK5 (0.70) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| Debromohymenialdisine SCHEMBL3578000 | 1.00 | CDK5 (0.70) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| Debromohymenialdisine SCHEMBL29358509 | 0.83 | CDK5 (1.00) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| Debromohymenialdisine SCHEMBL30092237 | 0.83 | CDK5 (1.00) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| Hymenialdisine SCHEMBL1249687 | 0.79 | CHEK2 (0.74) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| Hymenialdisine SCHEMBL1249686 | 0.79 | CHEK2 (0.74) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| Hymenialdisine SCHEMBL155899 | 0.79 | CHEK2 (0.74) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| SCHEMBL1250329 | 0.77 | CDK5 (0.73) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| SCHEMBL1250325 | 0.77 | CDK5 (0.73) | CDK5CDK5R1CHEK1CCNB2CDK1 | |
| Spongiacidin C SCHEMBL22480163 | 0.76 | PRKD3 (1.00) | CDK5CDK5R1CHEK1CCNB2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312390-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2009-12-17 | — | — | US | claimed |
| EP-1430120-A4 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA | ALCON INC (CH) | 2007-06-20 | — | — | EP | claimed |
| EP-1430120-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA | Alcon, Inc. (CH) | 2004-06-23 | — | — | EP | claimed |
| EP-1106180-B1 | Use of hymenialdisine or derivatives thereof in the manufacture of medicaments | CENTRE NAT RECH SCIENT (FR) | 2003-11-12 | — | — | EP | claimed |
| WO-2003027275-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2003-04-03 | — | — | WO | claimed |
| EP-0630245-B1 | PROTEIN KINASE C INHIBITOR | SMITHKLINE BEECHAM CORP (US) | 1999-01-20 | — | — | EP | claimed |
| US-5616577-A | Protein Kinase C inhibitor | SMITHKLINE BEECHAM CORPORATION | 1997-04-01 | — | — | US | claimed |
| US-5565448-A | Medicament | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-15 | — | — | US | claimed |
| EP-0630245-A1 | PROTEIN KINASE C INHIBITOR | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-28 | — | — | EP | claimed |
| EP-0630245-A4 | PROTEIN KINASE C INHIBITOR. | SMITHKLINE BEECHAM CORP (US) | 1994-11-02 | — | — | EP | claimed |
| WO-1993016703-A1 | PROTEIN KINASE C INHIBITOR | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | claimed |
| US-11541037-B2 | Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (HIV) | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2023-01-03 | — | — | US | disclosed |
| EP-3210017-B1 | ALKALOIDS FROM SPONGE, SCAFFOLDS FOR THE INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) | UNIV KING ABDULLAH SCI & TECH (SA) | 2021-10-06 | — | — | EP | disclosed |
| US-20200188359-A1 | ALKALOIDS FROM SPONGE, SCAFFOLDS FOR THE INHIBITIION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2020-06-18 | — | — | US | disclosed |
| US-10512633-B2 | Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (HIV) | KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY (SA) | 2019-12-24 | — | — | US | disclosed |
| US-5616577-A | Protein Kinase C inhibitor | SMITHKLINE BEECHAM CORPORATION | 1997-04-01 | — | — | US | disclosed |
| US-5565448-A | Medicament | SMITHKLINE BEECHAM CORPORATION (US) | 1996-10-15 | — | — | US | disclosed |
| EP-0630245-A1 | PROTEIN KINASE C INHIBITOR | SMITHKLINE BEECHAM CORPORATION (US) | 1994-12-28 | — | — | EP | disclosed |
| EP-0630245-A4 | PROTEIN KINASE C INHIBITOR. | SMITHKLINE BEECHAM CORP (US) | 1994-11-02 | — | — | EP | disclosed |
| WO-1993016703-A1 | PROTEIN KINASE C INHIBITOR | SMITHKLINE BEECHAM CORPORATION (US) | 1993-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312390-A1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA | GSK3B, GSK3A, GSKIP | CDK5 367/4885CDK5R1 778/4885CHEK1 650/4885 |
| US-10512633-B2 | Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (HIV) | SARS1, BCDIN3D, OCIAD1 | CDK5 1031/4885CDK5R1 1556/4885CHEK1 1261/4885 |
| US-11541037-B2 | Alkaloids from sponge, scaffolds for the inhibition of human immunodeficiency virus (HIV) | SARS1, BCDIN3D, OCIAD1 | CDK5 1031/4885CDK5R1 1556/4885CHEK1 1261/4885 |
| US-20200188359-A1 | ALKALOIDS FROM SPONGE, SCAFFOLDS FOR THE INHIBITIION OF HUMAN IMMUNODEFICIENCY VIRUS (HIV) | DHPS, OCIAD1, BCDIN3D | CDK5 1036/4885CDK5R1 1741/4885CHEK1 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.