Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369523 | 0.76 | BRD4 (0.46) | BRD4KDM4EALDH1A1SMN1; SMN2TDP2 | |
| SCHEMBL371317 | 0.73 | PARP1 (0.36) | BRD4KDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12505699 | 0.71 | CES1 (0.42) | BRD4KDM4EALDH1A1SMN1; SMN2TDP2 | |
| SCHEMBL17111287 | 0.68 | MEN1 (0.45) | KDM4EALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12505697 | 0.66 | CYP11B1 (0.41) | BRD4TACR1KDM4EALDH1A1SMN1; SMN2 | |
| Bicarbonate SCHEMBL8972762 | 0.66 | MYC (0.54) | BRD4KDM4EALDH1A1SMN1; SMN2PLA2G7 | |
| SCHEMBL27302249 | 0.64 | KDM4E (0.39) | BRD4KDM4EALDH1A1SMN1; SMN2ITGB1 | |
| SCHEMBL16021177 | 0.64 | BRD4 (0.43) | BRD4TACR1TDP2KMT2A | |
| SCHEMBL6529808 | 0.64 | POLB (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL28150024 | 0.64 | MEN1 (0.50) | ALDH1A1MEN1KMT2AMAPTPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |