Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12505693 | 0.73 | BRD4 (0.46) | MAPTPTGESALOX5ALDH1A1KDM4E | |
| SCHEMBL28563542 | 0.71 | NPC1 (0.47) | ALDH1A1KDM4EKMT2AHPGDBRD4 | |
| SCHEMBL17111287 | 0.68 | MEN1 (0.45) | MAPTALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL14241162 | 0.66 | NR1H4 (0.53) | MAPTSMN1; SMN2L3MBTL1 | |
| Bicarbonate SCHEMBL8972762 | 0.66 | MYC (0.54) | PPARGPPARAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3403133 | 0.65 | NAPRT (0.60) | MAPTALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL19952897 | 0.65 | MAPT (0.54) | PARP1PADI4MAPTALDH1A1KDM4E | |
| SCHEMBL16386608 | 0.65 | ALDH1A1 (0.57) | MAPTALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL2223763 | 0.64 | NOTUM (0.45) | PARP1PADI4ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL3182684 | 0.64 | SMN1; SMN2 (0.37) | PARP1PADI4MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F.HOFFMANN-LA ROCHE AG (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012007365-A1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-01-19 | — | — | WO | disclosed |