Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | ADCY1 | Q08828 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2190075 | 0.92 | CDC7 (0.55) | KDM4ESMN1; SMN2TP53PKMRAB9A | |
| SCHEMBL12507229 | 0.89 | TP53 (0.47) | KDM4ESMN1; SMN2TP53PKMRAB9A | |
| SCHEMBL2191201 | 0.84 | RAB9A (0.55) | KDM4ESMN1; SMN2TP53PKMRAB9A | |
| SCHEMBL13463231 | 0.79 | KDM4E (0.52) | KDM4ESMN1; SMN2TP53PKMRAB9A | |
| SCHEMBL2189787 | 0.78 | KDM4E (0.51) | KDM4ESMN1; SMN2TP53PKMRAB9A | |
| SCHEMBL12506950 | 0.73 | CDC7 (0.74) | KDM4ESMN1; SMN2CDC7CCNE1CDK2 | |
| SCHEMBL2190317 | 0.72 | CDC7 (0.58) | KDM4ESMN1; SMN2FLT3MAPTCDC7 | |
| SCHEMBL12907599 | 0.67 | CHEK1 (0.59) | KDM4ESMN1; SMN2TP53RAB9AMAPT | |
| SCHEMBL2188384 | 0.66 | CDK2 (0.52) | KDM4ESMN1; SMN2ADCY1MAPTCDC7 | |
| SCHEMBL25195476 | 0.66 | TLR8 (0.46) | CDC7CCNE1CDK2DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102197-B1 | 5-([1,3,4]OXADIAZOL-2-YL)-1H-INDAZOL AND 5-([1,3,4]THIADIAZOL-2-YL)-1H-INDAZOL DERIVATIVES AS SGK INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2011-07-13 | — | — | EP | disclosed |