Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 12/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | SCD | O00767 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984364 | 0.90 | RAB9A (0.64) | TP53MAPTRAB9ANPC1POLB | |
| SCHEMBL12509328 | 0.87 | TP53 (0.55) | TP53MAPTLMNARAB9ANPC1 | |
| SCHEMBL12421996 | 0.87 | TP53 (0.63) | TP53MAPTRXFP1LMNARAB9A | |
| SCHEMBL2193778 | 0.87 | MAPT (0.54) | TP53MAPTLMNARAB9ANPC1 | |
| SCHEMBL12509613 | 0.85 | MAPT (0.70) | TP53MAPTRXFP1LMNARAB9A | |
| SCHEMBL2191406 | 0.83 | TP53 (0.51) | TP53MAPTLMNARAB9ANPC1 | |
| SCHEMBL12422193 | 0.81 | MAPT (0.67) | TP53MAPTRXFP1LMNARAB9A | |
| SCHEMBL16623331 | 0.80 | APP (0.69) | MAPTRAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL2194594 | 0.80 | SCD (0.58) | TP53MAPTRXFP1LMNARAB9A | |
| SCHEMBL12421994 | 0.79 | MAPT (0.68) | TP53MAPTRXFP1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110171739-A1 | LIGANDS FOR AGGREGATED TAU MOLECULES | WISTA LABORATORIES LTD. | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171739-A1 | LIGANDS FOR AGGREGATED TAU MOLECULES | MAPT, PRNP, MAP4 | TP53 94/4885MAPT 1/4885RXFP1 3017/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.