Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 4/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.32 |
| ▸ | IGF1R | P08069 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3211479 | 0.90 | HDAC1 (0.47) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL1429937 | 0.90 | HDAC1 (0.47) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL2217180 | 0.85 | SLC7A5 (0.47) | HDAC1NAMPTGRIN2BCYP17A1SLC7A5 | |
| SCHEMBL2217184 | 0.85 | SLC7A5 (0.47) | HDAC1NAMPTGRIN2BCYP17A1SLC7A5 | |
| SCHEMBL13577799 | 0.82 | HDAC1 (0.45) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL7257280 | 0.79 | NAMPT (0.46) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL5076532 | 0.79 | NAMPT (0.47) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 | |
| SCHEMBL7260124 | 0.77 | NAMPT (0.44) | HDAC1NAMPTGRIN2BCYP17A1GSK3B | |
| SCHEMBL6058751 | 0.77 | NAMPT (0.44) | HDAC1NAMPTGRIN2BCYP17A1GSK3B | |
| SCHEMBL10087556 | 0.77 | NAMPT (0.49) | HDAC1NAMPTGRIN2BCYP17A1MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178130-A1 | MACROCYCLIC UREA AND SULFAMIDE DERIVATIVES AS INHIBITORS OF TAFIa | SANOFI-AVENTIS (FR) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178130-A1 | MACROCYCLIC UREA AND SULFAMIDE DERIVATIVES AS INHIBITORS OF TAFIa | TFPI, TFPI2, SERPINC1 | HDAC1 208/4885NAMPT 1007/4885GRIN2B 4680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.