Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.67 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.67 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.45 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.45 |
| ▸ | CHRNG | P07510 | 1/20 | 0.45 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRND | Q07001 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2083914 | 0.98 | CHRNB2 (0.69) | CHRNB2CHRNA4CYP11B2MKNK1MKNK2 | |
| SCHEMBL12949446 | 0.94 | CHRNB2 (0.69) | CHRNB2CHRNA4MKNK1MKNK2CHRNA3 | |
| Hydrochloric Acid SCHEMBL29877020 | 0.93 | CHRNB2 (0.67) | CHRNB2CHRNA4MKNK1MKNK2CHRNA3 | |
| Hydrochloric Acid SCHEMBL16823577 | 0.93 | CHRNB2 (0.67) | CHRNB2CHRNA4MKNK1MKNK2CHRNA3 | |
| SCHEMBL31276985 | 0.90 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL16845110 | 0.90 | CHRNB2 (0.67) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| Hydrochloric Acid SCHEMBL16823600 | 0.89 | CHRNB2 (0.65) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL3825648 | 0.85 | CHRNB2 (0.70) | CHRNB2CHRNA4MKNK1MKNK2CHRNA3 | |
| SCHEMBL7788072 | 0.84 | CHRNB2 (0.78) | CHRNB2CHRNA4MKNK1MKNK2CHRNA3 | |
| SCHEMBL3122156 | 0.84 | CHRNB2 (0.59) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523951-B1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2011088303-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES , INC. (US) | 2011-07-21 | — | — | WO | disclosed |
| WO-2011011303-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-01-27 | — | — | WO | disclosed |