Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10049851 | 0.89 | EGFR (0.53) | SYKEGFRAHRKDRMAPKAPK2 | |
| SCHEMBL30138092 | 0.89 | EGFR (0.53) | SYKEGFRAHRKDRMAPKAPK2 | |
| SCHEMBL12968742 | 0.83 | MAPKAPK2 (0.58) | SYKEGFRHTR3EHTR3BHTR3A | |
| Hydrochloric Acid SCHEMBL12821383 | 0.82 | MAPKAPK2 (0.56) | SYKEGFRHTR3EHTR3BHTR3A | |
| SCHEMBL6317977 | 0.79 | IGF1R (0.57) | — | |
| SCHEMBL31351683 | 0.79 | CYP1A2 (0.51) | EGFRKDRHTR3EHTR3BHTR3A | |
| SCHEMBL31351678 | 0.79 | CYP1A2 (0.51) | EGFRKDRHTR3EHTR3BHTR3A | |
| SCHEMBL12612817 | 0.78 | ROCK2 (0.55) | SYKEGFRKDRHTR3EHTR3B | |
| SCHEMBL12128995 | 0.77 | APP (0.67) | SYKAPPEGFRCMA1AHR | |
| SCHEMBL22803664 | 0.77 | SYK (0.50) | SYKAPPEGFRCMA1AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2688883-B1 | PYRIMIDINE DERIVATIVES | NOVIGA RES AB (SE) | 2016-05-18 | — | — | EP | disclosed |
| EP-2688883-B1 | PYRIMIDINE DERIVATIVES | NOVIGA RES AB (SE) | 2016-05-18 | — | — | EP | disclosed |
| US-9006241-B2 | Pyrimidine derivatives | NOVIGA RESEARCH AB (SE) | 2015-04-14 | — | — | US | disclosed |
| US-9006241-B2 | Pyrimidine derivatives | NOVIGA RESEARCH AB (SE) | 2015-04-14 | — | — | US | disclosed |
| CN-103619835-A | Novel pyrimidine derivatives | CHEMILIA AB | 2014-03-05 | — | — | CN | disclosed |
| US-20140045845-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2014-02-13 | — | — | US | disclosed |
| US-20140045845-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2014-02-13 | — | — | US | disclosed |
| EP-2688883-A1 | NOVEL PYRIMIDINE DERIVATIVES | Chemilia AB (SE) | 2014-01-29 | — | — | EP | disclosed |
| WO-2012127032-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2012-09-27 | — | — | WO | disclosed |
| WO-2012127032-A1 | NOVEL PYRIMIDINE DERIVATIVES | CHEMILIA AB (SE) | 2012-09-27 | — | — | WO | disclosed |
| EP-2502924-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2012-09-26 | — | — | EP | disclosed |
| EP-2502924-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2012-09-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045845-A1 | NOVEL PYRIMIDINE DERIVATIVES | TYMS, DPYD, TYMP | SYK 2886/4885APP 4085/4885EGFR 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.