Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21538558 | 0.85 | TSHR (0.42) | SOS1SOS2TSHR | |
| SCHEMBL19226779 | 0.82 | SOS1 (0.46) | SOS1SOS2TSHR | |
| SCHEMBL25862762 | 0.82 | SOS1 (0.37) | SOS1SOS2TSHR | |
| SCHEMBL20758383 | 0.80 | SOS1 (0.48) | SOS1SOS2TSHR | |
| SCHEMBL17624763 | 0.80 | SOS1 (0.40) | SOS1SOS2TSHR | |
| SCHEMBL25862089 | 0.80 | SOS1 (0.37) | SOS1SOS2TSHR | |
| SCHEMBL25792483 | 0.78 | SOS1 (0.41) | SOS1SOS2 | |
| SCHEMBL6012604 | 0.76 | SOS1 (0.44) | SOS1SOS2TSHR | |
| SCHEMBL9801465 | 0.76 | TSHR (0.36) | SOS1SOS2TSHR | |
| SCHEMBL24745284 | 0.75 | SOS1 (0.42) | SOS1SOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365563-A1 | QUINAZOLINE COMPOUND AND APPLICATION THEREOF | SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) | 2023-11-16 | — | — | US | disclosed |
| US-20230227470-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | VANDERBILT UNIVERSITY | 2023-07-20 | — | — | US | disclosed |
| WO-2022268063-A1 | CRYSTAL FORM OF PYRIMIDINE DERIVATIVE AND PREPARATION METHOD THEREFOR | 浙江海正药业股份有限公司 | 2022-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227470-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | KRAS, NRAS, TP53 | SOS1 1356/4885SOS2 1294/4885TSHR 1257/4885 |
| US-20230365563-A1 | QUINAZOLINE COMPOUND AND APPLICATION THEREOF | KRAS, NRAS, BRAF | SOS1 88/4885SOS2 235/4885TSHR 4687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.