Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 10/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | INPPL1 | O15357 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12524281 | 0.91 | MAP4K1 (0.47) | METNTRK1DYRK1AWNT1GSK3B | |
| SCHEMBL12441209 | 0.88 | MET (0.47) | METNTRK1DYRK1AWNT1INPPL1 | |
| SCHEMBL319690 | 0.85 | MET (0.52) | METNTRK1DYRK1AWNT1INPPL1 | |
| Formic Acid SCHEMBL13834691 | 0.84 | MET (0.44) | METNTRK1DYRK1AWNT1GSK3B | |
| SCHEMBL13835047 | 0.84 | MET (0.43) | METNTRK1DYRK1AWNT1INPPL1 | |
| SCHEMBL12440266 | 0.84 | MET (0.43) | METNTRK1DYRK1AWNT1INPPL1 | |
| SCHEMBL2325088 | 0.84 | MET (0.43) | METNTRK1DYRK1AWNT1INPPL1 | |
| SCHEMBL12439733 | 0.82 | MET (0.46) | METNTRK1DYRK1AWNT1GSK3B | |
| SCHEMBL2328767 | 0.81 | MET (0.42) | METNTRK1DYRK1AWNT1GSK3B | |
| SCHEMBL12440209 | 0.81 | MET (0.43) | METNTRK1DYRK1AWNT1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051318-B2 | Pyrido [2, 3-B] pyrazine compounds and their therapeutical uses such as for inhibiting ATP consuming proteins and treating diseases associated therewith | MERCK PATENT GMBH (DE) | 2015-06-09 | — | — | US | disclosed |
| US-9051318-B2 | Pyrido [2, 3-B] pyrazine compounds and their therapeutical uses such as for inhibiting ATP consuming proteins and treating diseases associated therewith | MERCK PATENT GMBH (DE) | 2015-06-09 | — | — | US | disclosed |
| EP-2683715-B1 | PYRIDO[2,3-B]PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | disclosed |
| WO-2012119690-A1 | PYRIDO [2, 3 - B] PYRAZINE DERIVATIVES AND THEIR THERAPEUTICAL USES | MERCK PATENT GMBH (DE) | 2012-09-13 | — | — | WO | disclosed |