Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | XBP1 | P17861 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12020641 | 0.86 | MAPT (0.60) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL693942 | 0.86 | MAPT (0.72) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL5142590 | 0.85 | MAPT (0.77) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL31236338 | 0.85 | MAPT (0.77) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL966420 | 0.85 | SMN1; SMN2 (0.68) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL5355449 | 0.84 | L3MBTL1 (0.64) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL21580306 | 0.84 | HTT (0.76) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL963689 | 0.83 | HDAC3 (0.70) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL26627751 | 0.83 | MAPT (0.72) | MAPTMEN1KMT2AGAAXBP1 | |
| SCHEMBL693941 | 0.83 | MAPT (0.72) | MAPTMEN1KMT2AGAAXBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012125661-A1 | SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANE DERIVATIVES USEFUL AS CCR2 ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2012-09-20 | — | — | WO | disclosed |