Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12065915 | 0.89 | — | — | |
| SCHEMBL19054663 | 0.82 | CHRNB2 (0.42) | TLR2SMN1; SMN2HTTSMYD3ULK1 | |
| SCHEMBL3211286 | 0.82 | CHRNB2 (0.42) | TLR2SMN1; SMN2HTTSMYD3ULK1 | |
| SCHEMBL1563436 | 0.82 | CHRNB2 (0.42) | TLR2SMN1; SMN2HTTSMYD3ULK1 | |
| SCHEMBL27802596 | 0.81 | HTT (0.36) | SMN1; SMN2HSD17B10HTTPOLBNAMPT | |
| Hydrochloric Acid SCHEMBL25329031 | 0.80 | CHRNB2 (0.41) | TLR2SMN1; SMN2HTTSMYD3ULK1 | |
| SCHEMBL13468900 | 0.80 | CHRNB2 (0.36) | SMYD3 | |
| Hydrochloric Acid SCHEMBL25329033 | 0.80 | CHRNB2 (0.41) | TLR2SMN1; SMN2HTTSMYD3ULK1 | |
| SCHEMBL2446419 | 0.79 | — | — | |
| SCHEMBL12116519 | 0.77 | HDAC8 (0.56) | SMN1; SMN2HSD17B10HTTMAPTHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012121361-A1 | DISPIROPYRROLIDINE DERIVATIVE | 第一三共株式会社 (JP) | 2012-09-13 | — | — | WO | disclosed |