Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12530555 | 0.90 | GRIN1 (0.48) | KMT2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6799664 | 0.82 | CYP19A1 (0.59) | KMT2APSEN1PSEN2APH1BNCSTN | |
| SCHEMBL12530552 | 0.79 | KMT2A (0.55) | KMT2AMAPTLMNARECQLNPC1 | |
| SCHEMBL14434265 | 0.79 | KMT2A (0.55) | KMT2ATP53MAPTNPC1ALDH1A1 | |
| SCHEMBL12530393 | 0.79 | MAPK1 (0.66) | KMT2ATP53MAPK1MAPTLMNA | |
| SCHEMBL14434548 | 0.73 | MAPT (0.64) | KMT2ATP53MAPK1MAPTLMNA | |
| SCHEMBL29019359 | 0.71 | MEN1 (0.56) | KMT2AMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6801401 | 0.71 | USP2 (0.47) | KMT2ANAMPTMAPTLMNAALDH1A1 | |
| SCHEMBL14902023 | 0.70 | NPC1 (0.58) | KMT2ATP53MAPK1LMNANPC1 | |
| SCHEMBL22233994 | 0.70 | KMT2A (0.57) | KMT2ATP53MAPK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703749-B2 | Compositions and methods for treating Friedreich's Ataxia | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2014-04-22 | — | — | US | disclosed |
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2013-05-02 | — | — | US | disclosed |
| WO-2011070444-A2 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | TESTI ROBERTO (IT) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | ATXN2, ATXN2L, ATXN10 | KMT2A 1775/4885PSEN1 21/4885PSEN2 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.