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Sugi Predict / Targets / ATXN2

ATXN2

Ataxin-2 · Q99700 · ATXN2 on Sugi Atlas →

8,104 patent compounds predicted against ATXN2, 3,470 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL143320 SCHEMBL143320 0.68 20/20
SCHEMBL119250 SCHEMBL119250 0.57 15/20
SCHEMBL118301 SCHEMBL118301 0.53 15/20
SCHEMBL118808 SCHEMBL118808 0.47 15/20
SCHEMBL117048 SCHEMBL117048 0.57 14/20
SCHEMBL118396 SCHEMBL118396 0.57 14/20
SCHEMBL118415 SCHEMBL118415 0.53 14/20
SCHEMBL118734 SCHEMBL118734 0.53 14/20
SCHEMBL117574 SCHEMBL117574 0.49 14/20
SCHEMBL117056 SCHEMBL117056 0.46 14/20
SCHEMBL118401 SCHEMBL118401 0.46 14/20
SCHEMBL118127 SCHEMBL118127 0.56 13/20
SCHEMBL118347 SCHEMBL118347 0.56 13/20
SCHEMBL118364 SCHEMBL118364 0.64 12/20
SCHEMBL117158 SCHEMBL117158 0.55 12/20
SCHEMBL104877 SCHEMBL104877 0.49 12/20
SCHEMBL119298 SCHEMBL119298 0.72 11/20
SCHEMBL104127 SCHEMBL104127 0.69 11/20
SCHEMBL104876 SCHEMBL104876 0.61 11/20
SCHEMBL117543 SCHEMBL117543 0.59 11/20

Clinical trials — most relevant to ATXN2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Clinical Trial With Riluzole in Spinocerebellar Ataxia Type 2 (ATRIL) PHASE3COMPLETED
A Safety and Pharmacokinetics Trial of VO659 in SCA1, SCA3 and HD PHASE1/PHASE2RECRUITING
Study of CAD-1883 for Spinocerebellar Ataxia PHASE2WITHDRAWN
An Open-labeled Phase II Study to Evaluate the Efficacy and Safety of GXNPC-1 in Patients with Chronic Stroke PHASE2COMPLETED
Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2 PHASE1RECRUITING
Clinical Trial Readiness for SCA1 and SCA3 nanUNKNOWN
Astrocytic Markers and the Pre-ataxic Period of SCA3/MJD - BIGPRO Study Astrocytes nanUNKNOWN
Natural History of Spinocerebellar Ataxia Type 7 (SCA7) nanRECRUITING
Natural History Study of and Genetic Modifiers in Spinocerebellar Ataxias nanUNKNOWN
Integrated Functional Evaluation of the Cerebellum nanCOMPLETED
Biomarkers in Autosomal Dominant Cerebellar Ataxia nanCOMPLETED
Investigating the Genetic and Phenotypic Presentation of Ataxia and Nucleotide Repeat Diseases nanACTIVE_NOT_RECRUITING
Natural History of Oculomotor Neurophysiology in Ataxic and Pre-ataxic Carriers of SCA3/MJD nanUNKNOWN
Slowing Down Disease Progression in Premanifest SCA: a Piloting Interventional Exergame Trial nanUNKNOWN
Hereditary Ataxia Research on Multi-Omics and Neuroclinical Insights in the Yangtze Delta nanRECRUITING
Ophthalmological Disorders in Dominant Spinal-cerebellar Ataxias nanRECRUITING
Hong Kong Spinocerebellar Ataxias Registry nanRECRUITING
The EUROSCA Natural History Study nanRECRUITING
Efficacy of Stabilometric Platform to Improve Standing Balance in Patients With Friedreich's Ataxia nanRECRUITING
Structural Validity and Inter-rater Reliabitiliy of the Ataxia Trunk, Lower And Upper Extremity Scale (ATLAS) nanNOT_YET_RECRUITING
Measuring Neurological Impairment and Functional Visual Assessment In Spinocerebellar Ataxias nanCOMPLETED
Gluten-Free Diet in Patients With Gluten Sensitivity and Cerebellar Ataxia nanCOMPLETED
Core Stability Exercises and Hereditary Ataxia nanCOMPLETED
Biomarker Research in Inherited Movement Disorders nanRECRUITING
Clinical and Molecular Correlations in Spinocerebellar Ataxia Type 10 (SCA10) nanCOMPLETED
FA Clinical Outcome Measures nanACTIVE_NOT_RECRUITING
Genetic Mechanism of Conserved Ancestral Haplotype in SCA10 nanUNKNOWN
Sporadic Degenerative Ataxia With Adult Onset: Natural History Study nanRECRUITING
Spinocerebellar Ataxia Type 27B Natural History Study (SCA27B-NHS) nanRECRUITING
Advancing Neurogenetic Diagnoses Through Long-Read Sequencing nanNOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a ATXN2 binder may also engage these)

ProteinNameSimilarity
O70305 — 0.999 O70305 →
Q8K2F8 — 0.981 Q8K2F8 →
O09000 — 0.980 O09000 →
Q5R4R4 — 0.980 Q5R4R4 →
Q62415 — 0.979 Q62415 →
Q6NZ18 — 0.979 Q6NZ18 →
Q9NRA8 — 0.979 Q9NRA8 →
A0A8M2 — 0.979 A0A8M2 →
Q5XJV7 — 0.978 Q5XJV7 →
Q8R205 — 0.978 Q8R205 →
Q3MHF8 — 0.978 Q3MHF8 →
Q8BZ47 — 0.978 Q8BZ47 →
Q8CGC4 — 0.978 Q8CGC4 →
Q96KQ4 — 0.977 Q96KQ4 →
Q7T2G1 — 0.977 Q7T2G1 →
Q4KKX4 — 0.977 Q4KKX4 →
Q8VHG2 — 0.977 Q8VHG2 →
Q96K80 — 0.977 Q96K80 →
O15014 — 0.977 O15014 →
Q86XZ4 — 0.976 Q86XZ4 →
Q498K9 — 0.976 Q498K9 →
Q5ZL54 — 0.976 Q5ZL54 →
A5D7H5 — 0.976 A5D7H5 →
Q91VX2 — 0.976 Q91VX2 →
Q64028 — 0.976 Q64028 →
Q8QG78 — 0.976 Q8QG78 →
Q9EST3 — 0.976 Q9EST3 →
Q13625 — 0.976 Q13625 →
O15234 — 0.976 O15234 →
Q62925 — 0.976 Q62925 →