Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1253112 | 0.79 | CNR2 (0.39) | CNR2MAPTMAPK13MAPK12MAPK11 | |
| SCHEMBL350333 | 0.77 | CNR2 (0.47) | SCN10ACNR2MAPTMAPK13MAPK12 | |
| SCHEMBL1250768 | 0.75 | CNR2 (0.39) | CNR2MAPTMAPK13MAPK12MAPK11 | |
| SCHEMBL351577 | 0.70 | CNR2 (0.49) | CNR2MAPTMAPK13MAPK12MAPK11 | |
| SCHEMBL10147583 | 0.70 | SCN10A (0.39) | SCN10ACNR2MAPTMAPK13MAPK12 | |
| SCHEMBL18415303 | 0.69 | KDM5B (0.36) | MAPTLMNACNR1 | |
| SCHEMBL18407334 | 0.68 | KDM4E (0.38) | SCN10ACNR2MAPTMAPK13MAPK12 | |
| SCHEMBL1250781 | 0.67 | CNR2 (0.39) | CNR2MAPTMAPK13MAPK12MAPK11 | |
| SCHEMBL1250777 | 0.67 | ALDH1A1 (0.34) | CNR2MAPK14ALDH1A1 | |
| SCHEMBL351120 | 0.65 | CNR2 (0.51) | CNR2MAPTMAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283001-A2 | SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | Boehringer Ingelheim International GmbH (DE) | 2011-02-16 | — | — | EP | claimed |
| WO-2009140089-A2 | SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-11-19 | — | — | WO | claimed |