Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.68 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1254554 | 0.96 | ROCK2 (0.69) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL1252383 | 0.91 | ROCK2 (0.66) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL1252379 | 0.91 | ROCK2 (0.66) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL1254217 | 0.88 | ROCK2 (0.76) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL12915044 | 0.87 | ROCK2 (0.62) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL1252558 | 0.87 | ROCK2 (0.71) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL1253660 | 0.86 | ROCK2 (0.54) | ROCK2ROCK1 | |
| SCHEMBL12915047 | 0.85 | ROCK2 (0.64) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL1252497 | 0.84 | ROCK2 (0.70) | ROCK2CDC42BPAROCK1 | |
| SCHEMBL15995994 | 0.82 | ROCK2 (0.61) | ROCK2CDC42BPAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110038835-A1 | ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-02-17 | — | — | US | disclosed |
| US-20110038835-A1 | ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-02-17 | — | — | US | disclosed |
| WO-2009079009-A1 | ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110038835-A1 | ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS | ROCK1, RHOA, ROCK2 | ROCK2 3/4885CDC42BPA 21/4885ROCK1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.