Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 4/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12365653 | 0.84 | MAPK1 (0.38) | KDM4EALDH1A1MYCKMT2A | |
| SCHEMBL14537390 | 0.83 | KDM4E (0.43) | KDM4ENOTUMALDH1A1RXFP1MYC | |
| SCHEMBL12365521 | 0.83 | KDM4E (0.43) | KDM4ENOTUMALDH1A1RXFP1MYC | |
| SCHEMBL12365531 | 0.79 | KDM4E (0.40) | KDM4ENOTUMALDH1A1RXFP1MYC | |
| SCHEMBL22055531 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1 | |
| SCHEMBL12365527 | 0.73 | ALDH1A1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL12365566 | 0.73 | ALDH1A1 (0.41) | KDM4EALDH1A1 | |
| SCHEMBL12365545 | 0.73 | ALDH1A1 (0.38) | KDM4EALDH1A1TDP1MEN1KMT2A | |
| SCHEMBL27634063 | 0.72 | KDR (0.39) | — | |
| SCHEMBL14651882 | 0.71 | SMN1; SMN2 (0.40) | KDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-08 | — | — | EP | disclosed |