Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12365545 | 0.83 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL12365587 | 0.80 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL12365549 | 0.80 | POLB (0.38) | ALDH1A1SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL12365658 | 0.77 | ALDH1A1 (0.33) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12365550 | 0.76 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2LMNAHTTMEN1 | |
| SCHEMBL24393051 | 0.76 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2LMNAHTTKDM4E | |
| SCHEMBL14651882 | 0.71 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2HTTKDM4EPOLB | |
| SCHEMBL12365546 | 0.70 | BRD4 (0.40) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12365531 | 0.67 | KDM4E (0.40) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL26116031 | 0.67 | ALDH1A1 (0.41) | ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948664-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-06-08 | — | — | EP | disclosed |