Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.57 |
| ▸ | MET | P08581 | 5/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | GRK2 | P25098 | 3/20 | 0.48 |
| ▸ | GRK5 | P34947 | 3/20 | 0.48 |
| ▸ | MAP4K3 | Q8IVH8 | 7/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | TYK2 | P29597 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12539482 | 0.96 | FGFR1 (0.57) | FGFR1FGFR2FGFR3METJAK2 | |
| SCHEMBL12538973 | 0.92 | FGFR1 (0.54) | FGFR1FGFR2FGFR3METJAK2 | |
| SCHEMBL12538901 | 0.90 | FGFR3 (0.56) | FGFR1FGFR2FGFR3METJAK2 | |
| SCHEMBL12539452 | 0.89 | FGFR1 (0.54) | FGFR1FGFR2FGFR3METJAK2 | |
| SCHEMBL12538733 | 0.88 | FGFR1 (0.54) | FGFR1FGFR2FGFR3METJAK2 | |
| SCHEMBL982736 | 0.85 | FGFR1 (0.53) | FGFR1FGFR2FGFR3METGRK2 | |
| SCHEMBL12539594 | 0.85 | FGFR1 (0.58) | FGFR1FGFR2FGFR3METJAK2 | |
| SCHEMBL12539061 | 0.83 | FGFR3 (0.55) | FGFR1FGFR2FGFR3METJAK2 | |
| SCHEMBL27900706 | 0.83 | FGFR3 (0.55) | FGFR1FGFR2FGFR3METJAK2 | |
| SCHEMBL987109 | 0.83 | JAK2 (0.56) | FGFR1FGFR2FGFR3METJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481524-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481524-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-09 | — | — | US | disclosed |
| US-20110136789-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110136789-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-09 | — | — | US | disclosed |
| EP-2205589-B1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009045992-A2 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136789-A1 | C-MET PROTEIN KINASE INHIBITORS | MET, PRKCH, ABL1 | FGFR1 133/4885FGFR2 177/4885FGFR3 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.