Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4887717 | 0.85 | MAPT (0.70) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL12541273 | 0.84 | MAPT (0.60) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL12540111 | 0.83 | GAA (0.58) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL12541011 | 0.82 | GAA (0.63) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL12540362 | 0.82 | MAPT (0.76) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL14950944 | 0.81 | MAPT (0.57) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL14950868 | 0.81 | MAPT (0.56) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL14950775 | 0.81 | MAPT (0.56) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL12540244 | 0.81 | NPC1 (0.57) | GAAMAPTMEN1ALDH1A1NPC1 | |
| SCHEMBL12540776 | 0.81 | MAPT (0.52) | GAAMAPTMEN1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245147-A1 | INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-09-27 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245147-A1 | INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH | HSPA5, HSP90B1, ATP2A1 | GAA 239/4885MAPT 2245/4885MEN1 3995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.