Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14950868 | 0.86 | MAPT (0.56) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL12542435 | 0.83 | MAPT (0.54) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL14950962 | 0.83 | MAPT (0.54) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL14950765 | 0.83 | MAPT (0.54) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL14940049 | 0.83 | MAPT (0.54) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL12541273 | 0.83 | MAPT (0.60) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL12541351 | 0.82 | ALDH1A1 (0.58) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL14950797 | 0.82 | MAPT (0.55) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL12540128 | 0.82 | MAPT (0.54) | MAPTGAAMEN1HTTALDH1A1 | |
| SCHEMBL12541017 | 0.81 | GAA (0.66) | MAPTGAAMEN1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013068592-A1 | INHIBITORS OF CYSTATHIONINE BETA SYNTHASE TO REDUCE THE NEUROTOXIC OVERPRODUCTION OF ENDOGENOUS HYDROGEN SULFIDE | FONDATION JEROME LEJEUNE (FR) | 2013-05-16 | — | — | WO | disclosed |