⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11562093 | 0.77 | — | — | |
| SCHEMBL60891 | 0.74 | — | — | |
| SCHEMBL180192 | 0.70 | — | — | |
| SCHEMBL5376851 | 0.70 | — | — | |
| SCHEMBL11244359 | 0.70 | — | — | |
| SCHEMBL407446 | 0.70 | — | — | |
| SCHEMBL539105 | 0.70 | — | — | |
| SCHEMBL18037093 | 0.70 | — | — | |
| SCHEMBL15064196 | 0.70 | — | — | |
| SCHEMBL2159908 | 0.68 | IDO1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116244-B1 | Method of treating atherosclerosis, dyslipidemias and related conditions | SCHERING CORP (US) | 2012-08-08 | — | — | EP | disclosed |
| US-20110118292-A1 | METHOD OF TREATING ATHEROSCLEROSIS, DYSLIPIDEMIAS AND RELATED CONDITIONS | CHENG KANG | 2011-05-19 | — | — | US | disclosed |
| EP-2286816-A1 | Method of treating atherosclerosis, dyslipidemias and related conditions | MERCK SHARP & DOHME (I.A.) CORP. (US) | 2011-02-23 | — | — | EP | disclosed |
| EP-1558614-B1 | PYRIDOPYRROLIZINE AND PYRIDOINDOLIZINE DERIVATIVES | MERCK FROSST CANADA LTD (CA) | 2010-09-01 | — | — | EP | disclosed |
| US-20100076002-A1 | Method of Treating Atherosclerosis, Dyslipidemias and Related Conditions and Pharmaceutical Compositions | CHENG KANG | 2010-03-25 | — | — | US | disclosed |
| US-7618979-B2 | Pyridopyrrolizine and pyridoindolizine derivatives | MERCK FROSST CANADA LTD. (CA) | 2009-11-17 | — | — | US | disclosed |
| EP-2116244-A1 | Method of treating atherosclerosis, dyslipidemias and related conditions | Merck & Co., Inc. (US) | 2009-11-11 | — | — | EP | disclosed |
| US-20090233977-A1 | Method of Treating Atherosclerosis, dyslipidemias and related conditions | MERCK SHARP & DOHME CORP. | 2009-09-17 | — | — | US | disclosed |
| EP-1809284-A4 | NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2009-09-09 | — | — | EP | disclosed |
| EP-1874301-A4 | NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO INC (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2006052555-A2 | NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2006-05-18 | — | — | WO | disclosed |
| WO-2006052798-A2 | METHOD OF TREATING PATHOLOGICAL BLUSHING | MERCK & CO., INC. (US) | 2006-05-18 | — | — | WO | disclosed |
| WO-2006026273-A2 | METHOD OF TREATING ATHEROSCLEROSIS, DYSLIPIDEMIAS AND RELATED CONDITIONS | MERCK & CO., INC. (US) | 2006-03-09 | — | — | WO | disclosed |
| EP-1624871-A1 | METHOD OF TREATING ATHEROSCLEROSIS, DYSLIPIDEMIAS AND RELATED CONDITIONS AND PHARMACEUTICAL COMPOSITIONS | Merck & Co., Inc. (a New Jersey corp.) (US) | 2006-02-15 | — | — | EP | disclosed |
| US-20050272756-A1 | Pyridopyrrolizine and pyridoindolizine derivatives | MERCK CANADA INC. (CA) | 2005-12-08 | — | — | US | disclosed |
| EP-1558614-A1 | PYRIDOPYRROLIZINE AND PYRIDOINDOLIZINE DERIVATIVES | Merck Frosst Canada & Co. (CA) | 2005-08-03 | — | — | EP | disclosed |
| WO-2004103370-A1 | METHOD OF TREATING ATHEROSCLEROSIS, DYSLIPIDEMIAS AND RELATED CONDITIONS AND PHARMACEUTICAL COMPOSITIONS | MERCK & CO., INC. (US) | 2004-12-02 | — | — | WO | disclosed |
| US-20040229844-A1 | Method of treating atherosclerosis, dyslipidemias and related conditions | CHENG KANG (US) | 2004-11-18 | — | — | US | disclosed |
| WO-2004039807-A1 | PYRIDOPYRROLIZINE AND PYRIDOINDOLIZINE DERIVATIVES | MERCK FROSST CANADA & CO. (CA) | 2004-05-13 | — | — | WO | disclosed |
| US-4350518-A | Plant growth regulating substituted alkylammonium salts | BASF AKTIENGESELLSCHAFT (DE) | 1982-09-21 | — | — | US | disclosed |