⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL191991 | 0.79 | — | — | |
| SCHEMBL224195 | 0.79 | — | — | |
| SCHEMBL9367007 | 0.75 | — | — | |
| SCHEMBL2347896 | 0.75 | — | — | |
| SCHEMBL2351350 | 0.75 | — | — | |
| SCHEMBL23531222 | 0.75 | — | — | |
| SCHEMBL3645962 | 0.75 | — | — | |
| SCHEMBL11095391 | 0.73 | NPC1 (0.32) | — | |
| SCHEMBL60891 | 0.72 | — | — | |
| SCHEMBL1254579 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11970485-B2 | RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2024-04-30 | — | — | US | claimed |
| US-20230265085-A1 | RET KINASE INHIBITORS | LOXO ONCOLOGY, INC. | 2023-08-24 | — | — | US | claimed |
| CN-116438179-A | Pyrazole derivatives as RET kinase inhibitors | 伊莱利利公司 | 2023-07-14 | — | — | CN | claimed |
| US-11697647-B2 | RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2023-07-11 | — | — | US | claimed |
| US-20220144816-A1 | RET KINASE INHIBITORS | EVOTEC INTERNATIONAL GMBH (DE) | 2022-05-12 | — | — | US | claimed |
| CN-106659721-B | Process for the preparation of a medicament | 基因泰克公司 | 2021-01-01 | — | — | CN | claimed |
| EP-3191492-B1 | P2X7 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-09 | — | — | EP | claimed |
| EP-2389066-B1 | CYCLOPENTADIONE DERIVED HERBICIDES | SYNGENTA LTD (GB) | 2017-07-05 | — | — | EP | claimed |
| US-20140378305-A1 | NOVEL HERBICIDES | SYNGENTA LIMITED (GB) | 2014-12-25 | — | — | US | claimed |
| US-8895474-B2 | Herbicidally active cyclopentanediones and derivatives thereof, and their use in controlling weeds | SYNGENTA LIMITED (GB) | 2014-11-25 | — | — | US | claimed |
| US-20120053053-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-01 | — | — | US | claimed |
| EP-2396306-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | Syngenta Limited (GB) | 2011-12-21 | — | — | EP | claimed |
| WO-2010092339-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS HERBICIDES | SYNGENTA LIMITED (GB) | 2010-08-19 | — | — | WO | claimed |
| US-11970485-B2 | RET kinase inhibitors | ELI LILLY AND COMPANY (US) | 2024-04-30 | — | — | US | disclosed |
| US-20230265085-A1 | RET KINASE INHIBITORS | LOXO ONCOLOGY, INC. | 2023-08-24 | — | — | US | disclosed |
| CN-116438179-A | Pyrazole derivatives as RET kinase inhibitors | 伊莱利利公司 | 2023-07-14 | — | — | CN | disclosed |
| EP-0442339-A2 | 3-Substituted pyridine methanols and fungicides containing them | BASF Aktiengesellschaft (DE) | 1991-08-21 | — | — | EP | disclosed |
| US-4175125-A | USING HALOGENATED PHENYLTHIOACETAMIDO CEPHALOSPORANIC ACID DERIVAT | ELI LILLY AND COMPANY (US) | 1979-11-20 | — | — | US | disclosed |
| US-4131672-A | HALOGENATED PHENYLTHIOACETAMIDO CEPHALOSPORANIC ACIDS | ELI LILLY AND COMPANY (US) | 1978-12-26 | — | — | US | disclosed |
| US-4056676-A | ANTIBIOTIC | ELI LILLY AND COMPANY (US) | 1977-11-01 | — | — | US | disclosed |