Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2608894 | 0.84 | HRH3 (0.47) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL12566580 | 0.82 | HRH3 (0.46) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL12712474 | 0.77 | HRH3 (0.53) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL14647730 | 0.77 | HRH3 (0.47) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL12810601 | 0.77 | HRH3 (0.47) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL26169754 | 0.77 | HRH3 (0.42) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL13201476 | 0.75 | HRH3 (0.46) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL19121404 | 0.74 | MLNR (0.41) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL30398570 | 0.73 | HRH3 (0.55) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E | |
| SCHEMBL487617 | 0.73 | HRH3 (0.55) | HRH3CYP1A2CYP2D6L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633206-B2 | Pyrrolo[2,3-D]pyrimidine compounds | PFIZER INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-20110136765-A1 | Pyrrolo[2,3-D]Pyrimidine Compounds | PFIZER INC. (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110136765-A1 | Pyrrolo[2,3-D]Pyrimidine Compounds | PFIZER INC. (US) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136765-A1 | Pyrrolo[2,3-D]Pyrimidine Compounds | JAK3, JAK1, JAK2 | HRH3 2464/4885CYP1A2 1425/4885CYP2D6 746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.