Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12554590 | 0.85 | KDM4E (0.51) | L3MBTL1KDM4EMAPK1ALDH1A1HTT | |
| SCHEMBL7573622 | 0.85 | L3MBTL1 (0.51) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12772533 | 0.85 | L3MBTL1 (0.54) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21074369 | 0.85 | L3MBTL1 (0.51) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11274332 | 0.84 | L3MBTL1 (0.58) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL31123647 | 0.84 | L3MBTL1 (0.58) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12554683 | 0.84 | L3MBTL1 (0.50) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12554698 | 0.83 | L3MBTL1 (0.49) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12554597 | 0.81 | KDM4E (0.41) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 | |
| SCHEMBL15150517 | 0.80 | L3MBTL1 (0.49) | L3MBTL1KDM4ECYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2013-08-01 | — | — | US | disclosed |
| US-8329742-B2 | Macrocyclic compounds useful as pharmaceuticals | EISAI CO., LTD. (JP) | 2012-12-11 | — | — | US | disclosed |
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | EISAI CO., LTD. (JP) | 2011-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144101-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT1, TBXA2R, VEGFA | L3MBTL1 3648/4885KDM4E 2910/4885CYP1A2 983/4885 |
| US-20130196987-A1 | MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS | FLT4, VEGFA, FLT1 | L3MBTL1 4679/4885KDM4E 3027/4885CYP1A2 2083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.