Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 7/20 | 0.66 |
| ▸ | KDR | P35968 | 7/20 | 0.66 |
| ▸ | AXL | P30530 | 2/20 | 0.66 |
| ▸ | FLT3 | P36888 | 2/20 | 0.66 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.66 |
| ▸ | KIT | P10721 | 1/20 | 0.66 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.66 |
| ▸ | MST1R | Q04912 | 14/20 | 0.61 |
| ▸ | PLK4 | O00444 | 1/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.61 |
| ▸ | ABL1 | P00519 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | FYN | P06241 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | HCK | P08631 | 1/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.61 |
| ▸ | BCR | P11274 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | ABL2 | P42684 | 1/20 | 0.61 |
| ▸ | FRK | P42685 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12557947 | 0.96 | MET (0.64) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL2539359 | 0.94 | MET (0.64) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL1478899 | 0.93 | MET (0.76) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL12558429 | 0.93 | MET (0.61) | METKDRAXLFLT3NTRK1 | |
| Hydrochloric Acid SCHEMBL1479074 | 0.92 | MET (0.75) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL2539405 | 0.92 | MET (0.63) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL1479321 | 0.92 | MET (0.70) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL1479292 | 0.91 | MET (0.61) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL1479435 | 0.91 | MET (0.70) | METKDRAXLFLT3NTRK1 | |
| SCHEMBL1478448 | 0.91 | MET (0.70) | METKDRAXLFLT3NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2332536-A1 | Inhibitors of protein tyrosine kinase activity | MethylGene Inc. (CA) | 2011-06-15 | — | — | EP | disclosed |