Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.33 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12574631 | 0.88 | SMN1; SMN2 (0.36) | GRM5SMN1; SMN2CYP1A2CYP2C9HPGD | |
| SCHEMBL12638382 | 0.87 | GFER (0.37) | SMN1; SMN2NPC1RAB9AZAP70KARS1 | |
| SCHEMBL12574800 | 0.85 | GRM5 (0.40) | GRM5SMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL12574734 | 0.83 | GRM5 (0.37) | GRM5SMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL12575006 | 0.82 | ALDH1A1 (0.34) | PTK2SMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL12574749 | 0.82 | GRM5 (0.33) | GRM5ZAP70KARS1KDM4EMAPT | |
| SCHEMBL12574676 | 0.81 | GRM5 (0.35) | GRM5SMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL12574685 | 0.81 | KDM4E (0.41) | SMN1; SMN2NPC1RAB9AHPGDZAP70 | |
| SCHEMBL12574657 | 0.80 | GRM5 (0.39) | GRM5SMN1; SMN2NPC1RAB9ACYP1A2 | |
| SCHEMBL12574807 | 0.80 | HPGD (0.35) | GRM5CYP1A2CYP2C9HPGDCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329705-B2 | Substituted triazolo-pyrazine compounds | ARQULE, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | ARQULE, INC. (US) | 2011-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160215-A1 | Substituted Triazolo-Pyrazine Compounds | MKI67, TP53, THPO | GRM5 607/4885PTK2 1746/4885SMN1; SMN2 3947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.