Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 1.00 |
| ▸ | KDR | P35968 | 11/20 | 0.71 |
| ▸ | KIT | P10721 | 8/20 | 0.71 |
| ▸ | PDGFRA | P16234 | 8/20 | 0.71 |
| ▸ | FLT1 | P17948 | 3/20 | 0.71 |
| ▸ | FLT4 | P35916 | 3/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | JAK2 | O60674 | 2/20 | 0.71 |
| ▸ | JAK3 | P52333 | 2/20 | 0.71 |
| ▸ | LYN | P07948 | 2/20 | 0.71 |
| ▸ | TXK | P42681 | 2/20 | 0.71 |
| ▸ | SYK | P43405 | 2/20 | 0.71 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.71 |
| ▸ | PLK4 | O00444 | 1/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.71 |
| ▸ | GAK | O14976 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL724300 | 0.88 | BTK (0.79) | BTKKDRKITPDGFRAFLT1 | |
| Hydrochloric Acid SCHEMBL159486 | 0.88 | BTK (0.77) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL1958890 | 0.87 | BTK (0.77) | BTKKDRKITPDGFRAFLT1 | |
| Hydrochloric Acid SCHEMBL935691 | 0.87 | BTK (0.76) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL4427732 | 0.86 | BTK (0.75) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL24956798 | 0.84 | KDR (0.74) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL29884143 | 0.84 | BTK (0.73) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL28843997 | 0.84 | BTK (0.73) | BTKKDRKITPDGFRAFLT1 | |
| Pazopanib SCHEMBL29392503 | 0.83 | KDR (1.00) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL12922972 | 0.83 | BTK (0.71) | BTKKDRKITPDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011069053-A1 | PROCESS FOR THE PREPARATION OF PAZOPANIP HCL AND CRYSTALLINE FORMS OF PAZOPANIB HCL | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2011-06-09 | — | — | WO | disclosed |