Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.71 |
| ▸ | KDR | P35968 | 15/20 | 0.65 |
| ▸ | KIT | P10721 | 9/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 9/20 | 0.65 |
| ▸ | FLT1 | P17948 | 4/20 | 0.65 |
| ▸ | FLT4 | P35916 | 4/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.65 |
| ▸ | STK16 | O75716 | 2/20 | 0.65 |
| ▸ | CSF1R | P07333 | 2/20 | 0.65 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.65 |
| ▸ | TAOK2 | Q9UL54 | 2/20 | 0.65 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.65 |
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | GAK | O14976 | 1/20 | 0.65 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12575010 | 0.83 | BTK (1.00) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL29884143 | 0.81 | BTK (0.73) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL28843997 | 0.81 | BTK (0.73) | BTKKDRKITPDGFRAFLT1 | |
| Pazopanib SCHEMBL588608 | 0.79 | KDR (1.00) | BTKKDRKITPDGFRAFLT1 | |
| Pazopanib SCHEMBL29392503 | 0.79 | KDR (1.00) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL4991594 | 0.79 | BTK (0.71) | BTKKDRKITPDGFRAFLT1 | |
| Pazopanib SCHEMBL29386934 | 0.78 | KDR (0.98) | BTKKDRKITPDGFRAFLT1 | |
| Pazopanib SCHEMBL159487 | 0.78 | KDR (0.98) | BTKKDRKITPDGFRAFLT1 | |
| Pazopanib SCHEMBL29520402 | 0.78 | KDR (0.98) | BTKKDRKITPDGFRAFLT1 | |
| SCHEMBL724300 | 0.78 | BTK (0.79) | BTKKDRKITPDGFRAFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349861-B2 | Methods for identification of JAK kinase interacting molecules and for the purification of JAK kinases | CELLZOME AG (DE) | 2013-01-08 | — | — | US | disclosed |
| US-20110039718-A1 | METHODS FOR IDENTIFICATION OF JAK KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF JAK KINASES | CELLZOME AG (DE) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039718-A1 | METHODS FOR IDENTIFICATION OF JAK KINASE INTERACTING MOLECULES AND FOR THE PURIFICATION OF JAK KINASES | JAK2, JAK3, JAK1 | BTK 25/4885KDR 1021/4885KIT 715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.