Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | GFER | P55789 | 3/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11983452 | 0.76 | ALDH1A1 (0.60) | MAPTKDM4EGAAALDH1A1CREBBP | |
| SCHEMBL12575364 | 0.75 | ATR (0.38) | ALDH1A1BRPF1MEN1KMT2ATDP1 | |
| SCHEMBL9950301 | 0.74 | KDM4E (0.40) | MAPTKDM4EALDH1A1CREBBPPOLB | |
| SCHEMBL252411 | 0.74 | KMT2A (0.41) | MAPTKDM4EGAAALDH1A1CREBBP | |
| SCHEMBL16190092 | 0.74 | NPY5R (0.39) | MAPTKDM4EALDH1A1CREBBPPOLB | |
| SCHEMBL25153722 | 0.74 | MAP2K2 (0.40) | MAPTKDM4EALDH1A1CREBBPSMN1; SMN2 | |
| SCHEMBL3401026 | 0.74 | CREBBP (0.39) | MAPTKDM4EALDH1A1CREBBPSMN1; SMN2 | |
| SCHEMBL15393378 | 0.74 | CREBBP (0.39) | MAPTKDM4EALDH1A1CREBBPSMN1; SMN2 | |
| SCHEMBL12217560 | 0.74 | CREBBP (0.42) | MAPTKDM4EALDH1A1CREBBPSMN1; SMN2 | |
| SCHEMBL15360158 | 0.74 | MAPT (0.50) | MAPTKDM4EALDH1A1CREBBPSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084801-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118084800-A | Compounds and uses thereof | 詹森药业有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-112312913-B | Compounds and uses thereof | 詹森药业有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-114174273-A | Compounds and uses thereof | 优曼尼蒂治疗公司 | 2022-03-11 | — | — | CN | disclosed |
| EP-3941908-A1 | COMPOUNDS AND USES THEREOF | Yumanity Therapeutics, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| WO-2020198026-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2020-10-01 | — | — | WO | disclosed |
| WO-2019183587-A1 | COMPOUNDS AND USES THEREOF | YUMANITY THERAPEUTICS, INC. (US) | 2019-09-26 | — | — | WO | disclosed |
| EP-3061752-B1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | XCOVERY HOLDING CO LLC (US) | 2018-02-21 | — | — | EP | disclosed |
| EP-3061752-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | Xcovery Holding Company LLC (US) | 2016-08-31 | — | — | EP | disclosed |
| US-20160176900-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | TYROGENEX, INC. | 2016-06-23 | — | — | US | disclosed |
| US-9242958-B2 | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds | XCOVERY HOLDING COMPANY LLC (US) | 2016-01-26 | — | — | US | disclosed |
| US-9242958-B2 | Substituted pyridazine carboxamide compounds as kinase inhibitor compounds | XCOVERY HOLDING COMPANY LLC (US) | 2016-01-26 | — | — | US | disclosed |
| EP-2303018-B1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | XCOVERY HOLDING CO LLC (US) | 2015-10-14 | — | — | EP | disclosed |
| US-20140221376-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | XCOVERY HOLDING COMPANY, LLC (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221376-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | XCOVERY HOLDING COMPANY, LLC (US) | 2014-08-07 | — | — | US | disclosed |
| US-20130203763-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | XCOVERY HOLDING COMPANY, LLC (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130203763-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | XCOVERY HOLDING COMPANY, LLC (US) | 2013-08-08 | — | — | US | disclosed |
| US-20110160209-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | TYROGENEX, INC. | 2011-06-30 | — | — | US | disclosed |
| US-20110160209-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | TYROGENEX, INC. | 2011-06-30 | — | — | US | disclosed |
| WO-2009154769-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | XCOVERY, INC. (US) | 2009-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160209-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | MAP4K2, MAP3K15, MAP3K5 | MAPT 2071/4885KDM4E 935/4885GAA 2454/4885 |
| US-20140221376-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | MAP4K2, MAP3K15, MAP3K5 | MAPT 2071/4885KDM4E 935/4885GAA 2454/4885 |
| US-20160176900-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | MAP4K2, MAP3K15, MAP3K5 | MAPT 2071/4885KDM4E 935/4885GAA 2454/4885 |
| US-20130203763-A1 | SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS | MAP4K2, MAP3K15, MAP3K5 | MAPT 2303/4885KDM4E 699/4885GAA 4219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.