Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Butyric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.68 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.68 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.44 |
| ▸ | PPARG | P37231 | 7/20 | 0.44 |
| ▸ | PPARD | Q03181 | 7/20 | 0.44 |
| ▸ | PPARA | Q07869 | 7/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.44 |
| ▸ | FABP4 | P15090 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL8937174 | 0.95 | FFAR3 (0.62) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL15261051 | 0.95 | FFAR3 (0.77) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL1257810 | 0.95 | — | — | |
| Butyric Acid SCHEMBL10338134 | 0.95 | FFAR3 (0.77) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL11243328 | 0.92 | FFAR3 (0.72) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL30532231 | 0.92 | FFAR3 (0.72) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL385002 | 0.89 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL11852319 | 0.89 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL9215318 | 0.89 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 | |
| Butyric Acid SCHEMBL9115265 | 0.89 | FFAR3 (0.87) | FFAR3HDAC3HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9243072-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2016-01-26 | — | — | US | disclosed |
| US-9150665-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2015-10-06 | — | — | US | disclosed |
| US-9040683-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040684-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040685-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2015-05-26 | — | — | US | disclosed |
| US-8816066-B2 | Cellulose interpolymers and methods of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130203982-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130131333-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130116426-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-05-09 | — | — | US | disclosed |
| US-20130116425-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-05-09 | — | — | US | disclosed |
| US-20130116427-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-05-09 | — | — | US | disclosed |
| EP-2532684-A2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2532683-A2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2012-12-12 | — | — | EP | disclosed |
| US-20110098464-A1 | CELLULOSE INTERPOLYMERS AND METHODS OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2011-04-28 | — | — | US | disclosed |
| US-7879994-B2 | For use as binder resins and drug delivery agents; bioavailability | EASTMAN CHEMICAL COMPANY (US) | 2011-02-01 | — | — | US | disclosed |
| EP-1689787-A2 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2006-08-16 | — | — | EP | disclosed |
| US-20050192434-A1 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY | 2005-09-01 | — | — | US | disclosed |
| WO-2005054297-A2 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2005-06-16 | — | — | WO | disclosed |