Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1965574 | 0.82 | MAPT (0.43) | HTR3AMAPTACKR3MCHR1 | |
| SCHEMBL12059959 | 0.66 | MCHR1 (0.57) | MAPTMCHR1 | |
| SCHEMBL1967313 | 0.65 | HTR3A (0.57) | HTR3AMAPTCDK5CDK2CDK9 | |
| SCHEMBL1967319 | 0.65 | HTR3A (0.57) | HTR3AMAPTCDK5CDK2CDK9 | |
| SCHEMBL12582575 | 0.63 | DYRK1A (0.47) | — | |
| SCHEMBL30034264 | 0.62 | SMN1; SMN2 (0.88) | MAPT | |
| SCHEMBL3454750 | 0.61 | EPHX2 (1.00) | MAPTEPHX2 | |
| SCHEMBL5049577 | 0.61 | EPHX2 (1.00) | MAPTEPHX2 | |
| SCHEMBL1278783 | 0.61 | KMT2A (0.52) | HRH3 | |
| SCHEMBL11823684 | 0.61 | DRD4 (0.61) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336128-A1 | Benzoisothiazoles and preparation and uses thereof | Memory Pharmaceuticals Corporation (US) | 2011-06-22 | — | — | EP | disclosed |