Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oleamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.51 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | FABP3 | P05413 | 7/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oleamide SCHEMBL1258565 | 1.00 | FAAH (0.51) | FAAHSOAT1MEN1TP53CYP1A2 | |
| Oleamide SCHEMBL1281695 | 0.94 | FAAH (0.57) | FAAHSOAT1MEN1TP53CYP1A2 | |
| Oleamide SCHEMBL1281693 | 0.94 | FAAH (0.57) | FAAHSOAT1MEN1TP53CYP1A2 | |
| Monoethanolamine SCHEMBL27902081 | 0.91 | FFAR1 (0.50) | FAAHSOAT1MEN1TP53CYP1A2 | |
| Dectaflur SCHEMBL28705927 | 0.88 | EPHX2 (0.48) | FAAHEPHX2FABP3SLC6A5 | |
| Oleyl Alcohol SCHEMBL28032267 | 0.88 | EPHX2 (0.50) | EPHX2FABP3CNR1SLC6A5 | |
| Monoethanolamine SCHEMBL4758122 | 0.87 | FAAH (0.39) | FAAHSOAT1MEN1TP53CYP1A2 | |
| Oleic Acid SCHEMBL6270897 | 0.87 | FABP3 (0.63) | FAAHEPHX2FABP3SLC6A5 | |
| Octadecanoic Acid Amide SCHEMBL1262909 | 0.87 | TP53 (0.42) | FAAHSOAT1MEN1TP53CYP1A2 | |
| Monoethanolamine SCHEMBL4759394 | 0.86 | FAAH (0.38) | FAAHSOAT1MEN1TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114630666-A | Method of reducing side effects of administration of phosphodiesterase-4 inhibitors | 阿尔库缇斯生物疗法股份有限公司 | 2022-06-14 | — | — | CN | disclosed |
| US-9243072-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2016-01-26 | — | — | US | disclosed |
| US-9150665-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2015-10-06 | — | — | US | disclosed |
| US-9040683-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040685-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2015-05-26 | — | — | US | disclosed |
| US-9040684-B2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2015-05-26 | — | — | US | disclosed |
| US-8816066-B2 | Cellulose interpolymers and methods of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130203982-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-08-08 | — | — | US | disclosed |
| US-20130131333-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-05-23 | — | — | US | disclosed |
| US-20130116427-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-05-09 | — | — | US | disclosed |
| US-20130116426-A1 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2013-05-09 | — | — | US | disclosed |
| EP-2532684-A2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2012-12-12 | — | — | EP | disclosed |
| EP-2532683-A2 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY (US) | 2012-12-12 | — | — | EP | disclosed |
| US-20110098464-A1 | CELLULOSE INTERPOLYMERS AND METHODS OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2011-04-28 | — | — | US | disclosed |
| US-7879994-B2 | For use as binder resins and drug delivery agents; bioavailability | EASTMAN CHEMICAL COMPANY (US) | 2011-02-01 | — | — | US | disclosed |
| EP-1689787-A2 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2006-08-16 | — | — | EP | disclosed |
| US-6998114-B2 | Hair grooming formulations and methods for the use thereof | EASTMAN CHEMICAL COMPANY (US) | 2006-02-14 | — | — | US | disclosed |
| US-20050192434-A1 | Cellulose interpolymers and method of oxidation | EASTMAN CHEMICAL COMPANY | 2005-09-01 | — | — | US | disclosed |
| WO-2005054297-A2 | CELLULOSE INTERPOLYMERS AND METHOD OF OXIDATION | EASTMAN CHEMICAL COMPANY (US) | 2005-06-16 | — | — | WO | disclosed |
| US-20030147829-A1 | Hair grooming formulations and methods for the use thereof | EASTMAN CHEMICAL COMPANY | 2003-08-07 | — | — | US | disclosed |