Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP28 | Q96RU2 | 9/20 | 0.82 |
| ▸ | ALB | P02768 | 1/20 | 0.82 |
| ▸ | HTR1A | P08908 | 1/20 | 0.82 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.82 |
| ▸ | PDE4A | P27815 | 1/20 | 0.82 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.82 |
| ▸ | DRD3 | P35462 | 1/20 | 0.82 |
| ▸ | HTR2B | P41595 | 1/20 | 0.82 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.82 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.82 |
| ▸ | SHH | Q15465 | 1/20 | 0.82 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.82 |
| ▸ | SMO | Q99835 | 1/20 | 0.82 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12917417 | 0.94 | USP28 (0.79) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12918159 | 0.94 | USP28 (0.75) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12917387 | 0.94 | USP28 (0.78) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12917384 | 0.93 | USP28 (0.76) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12917437 | 0.93 | USP28 (0.76) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12917078 | 0.93 | USP28 (0.79) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12917107 | 0.93 | USP28 (0.79) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12917436 | 0.92 | USP28 (0.75) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12917005 | 0.92 | USP28 (0.75) | USP28ALBHTR1ASLC6A2PDE4A | |
| SCHEMBL12916988 | 0.92 | USP28 (0.78) | USP28ALBHTR1ASLC6A2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011014888-A1 | NOVEL HEDGEHOG INHIBITORS | SELEXAGEN THERAPEUTICS (US) | 2011-02-03 | — | — | WO | disclosed |
| WO-2011014888-A1 | NOVEL HEDGEHOG INHIBITORS | SELEXAGEN THERAPEUTICS (US) | 2011-02-03 | — | — | WO | disclosed |