Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 12/20 | 1.00 |
| ▸ | RPS6KA2 | Q15349 | 10/20 | 0.79 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.79 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.79 |
| ▸ | RET | P07949 | 1/20 | 0.79 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.79 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.79 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.79 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.79 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.79 |
| ▸ | FLT3 | P36888 | 1/20 | 0.79 |
| ▸ | CLK1 | P49759 | 1/20 | 0.79 |
| ▸ | CLK2 | P49760 | 1/20 | 0.79 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.79 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.79 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.79 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14973127 | 0.93 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL12595454 | 0.93 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL1984978 | 0.89 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL1979440 | 0.88 | RPS6KA2 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL1980595 | 0.88 | RPS6KA2 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL1981288 | 0.88 | RPS6KA2 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL31060674 | 0.88 | RPS6KA2 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL14973160 | 0.87 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL12595293 | 0.87 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET | |
| SCHEMBL14972925 | 0.87 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2PRKD3ADRB2RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2509979-B1 | HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE | BOEHRINGER INGELHEIM INT (DE) | 2016-05-25 | — | — | EP | disclosed |
| EP-2509979-B1 | HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE | BOEHRINGER INGELHEIM INT (DE) | 2016-05-25 | — | — | EP | disclosed |
| US-9073926-B2 | Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| US-9073926-B2 | Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| US-9073926-B2 | Heterocyclic compounds containing a pyrrolopyridine or benzimidazole core | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-07-07 | — | — | US | disclosed |
| US-20130137680-A1 | HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-30 | — | — | US | disclosed |
| US-20130137680-A1 | HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-30 | — | — | US | disclosed |
| WO-2011071725-A1 | HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137680-A1 | HETEROCYCLIC COMPOUNDS CONTAINING A PYRROLOPYRIDINE OR BENZIMIDAZOLE CORE | PKD1, PAH, JAK2 | RPS6KA3 955/4885RPS6KA2 1164/4885PRKD3 546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.