Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | WRN | Q14191 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17635563 | 0.86 | CYP2A6 (0.48) | APPCYP2A6PGRARMAPT | |
| SCHEMBL12208049 | 0.83 | CYP2A6 (0.50) | APPCYP2A6PGRARMAPT | |
| SCHEMBL12208206 | 0.80 | CYP2A6 (0.50) | APPCYP2A6PGRARMAPT | |
| SCHEMBL22834331 | 0.80 | APP (0.71) | APPCYP2A6PGRARMAPT | |
| SCHEMBL12231917 | 0.77 | CYP2A6 (0.54) | APPCYP2A6PGRARMAPT | |
| SCHEMBL12597661 | 0.77 | ATG4B (0.43) | MAPTHTTKMT2AMEN1ALDH1A1 | |
| SCHEMBL10489736 | 0.74 | CYP2A6 (0.54) | APPCYP2A6PGRARMAPT | |
| SCHEMBL8645298 | 0.74 | CYP2A6 (0.54) | APPCYP2A6PGRARMAPT | |
| SCHEMBL3156456 | 0.74 | MAPT (0.54) | MAPTKDM4EHTTGAAPOLB | |
| SCHEMBL12598669 | 0.74 | CYP2A6 (0.35) | APPCYP2A6PGRARMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336141-A2 | Phosphoramidate alkylator prodrugs | Threshold Pharmaceuticals, Inc. (US) | 2011-06-22 | — | — | EP | disclosed |