ATG4B

Cysteine protease ATG4B · Q9Y4P1 · ATG4B on Sugi Atlas →

76,874 patent compounds predicted against ATG4B, 53,392 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL143499	1.00	20/20
SCHEMBL176983	0.49	9/20
SCHEMBL176984	0.49	9/20
SCHEMBL91914	0.46	9/20
SCHEMBL82569	0.66	7/20
Fumaric Acid (SCHEMBL48773)	0.41	6/20
Fumaric Acid (SCHEMBL152140)	0.41	6/20
SCHEMBL177586	0.51	5/20
Nithiamide (SCHEMBL158858)	0.63	4/20
9,10-Phenanthrenequinone (SCHEMBL43050)	1.00	3/20
SCHEMBL40960	0.87	3/20
Epalrestat (SCHEMBL49048)	0.76	3/20
Epalrestat (SCHEMBL49049)	0.76	3/20
SCHEMBL75643	0.59	3/20
SCHEMBL75644	0.59	3/20
SCHEMBL158152	0.58	3/20
Hydrochloric Acid (SCHEMBL98010)	0.57	3/20
Hydrochloric Acid (SCHEMBL99575)	0.57	3/20
SCHEMBL151548	0.55	3/20
SCHEMBL81693	0.53	3/20

Clinical trials — most relevant to ATG4B by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Azithromycin Plus Hydroxychloroquine for COVID-19 Infection	PHASE3	WITHDRAWN
Effects of Cannabidiol (CBD) on the Activation of Autophagy and Inflammation Genes, Functional Consequences in Virologically Controlled HIV-infected Patients	PHASE2	COMPLETED
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)	PHASE1/PHASE2	NOT_YET_RECRUITING
FOLFOX/Bevacizumab/Hydroxychloroquine (HCQ) in Colorectal Cancer	PHASE1/PHASE2	COMPLETED
A Study of Hydroxychloroquine in Combination With Gemcitabine/Abraxane in Pancreatic Cancer	PHASE1/PHASE2	COMPLETED
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients	PHASE2	UNKNOWN
A Phase II Single-arm Intervention Trial of Nelfinavir in Patients With Grade 2/3 or 3 Cervical Intraepithelial Neoplasia	PHASE2	WITHDRAWN
ATG Individualized Dosing Model in URD-PBSCT.	PHASE2	RECRUITING
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction	EARLY_PHASE1	RECRUITING
Autophagy in Systemic Lupus Erythematosus	nan	UNKNOWN
Autophagy Bladder Cancer	nan	UNKNOWN
Fasting, Exercise, and Diet to Activate Autophagy in Depression	nan	NOT_YET_RECRUITING
The Influence of Autophagy on Fatty Liver	nan	UNKNOWN
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population	nan	COMPLETED
Diagnostic Potential of UCHL1 in Acute Decompensated Heart Failure	nan	COMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Study on the Correlation Between Alveolar Macrophage-derived Autophagosomes and the Severity of Lung Injury in ARDS	nan	UNKNOWN
Time Course for Fasting-induced Autophagy in Humans	nan	WITHDRAWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
Autophagy/Apoptosis Balance in Placental Vascular Pathologies	nan	RECRUITING
Muscle Insulin Resistance in Aging (Mirage)	nan	ACTIVE_NOT_RECRUITING
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Intermittent Fasting for Pancreatitis	nan	NOT_YET_RECRUITING
Autophagy, Oxidative Stress and Hippo Signaling in Human Aortic Aneurysm	nan	COMPLETED
Autophagy Markers in Endometrial Polyps	nan	COMPLETED
2-A-Day Study: Twice a Day Meals Study.	nan	COMPLETED
Differential Gene Expression of Liver Tissue and Blood From Individuals With Chronic Viral Hepatitis	nan	UNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Evaluation of Serum Gasdermin D Level As a Potential Biomarker of Disease Activity in Vitiligo Patients	nan	UNKNOWN
Susceptibility Genes in Autism Spectrum Disorders	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ATG4B binder may also engage these)

Protein	Name	Similarity
Q8BGE6	—	1.000	Q8BGE6 →
Q6PZ02	—	0.996	Q6PZ02 →
A0A0G2QC33	—	0.994	A0A0G2QC33 →
Q6PZ03	—	0.985	Q6PZ03 →
Q640G7	—	0.982	Q640G7 →
Q6DG88	—	0.979	Q6DG88 →
Q5ZIW7	—	0.965	Q5ZIW7 →
Q5R699	—	0.963	Q5R699 →
Q5BJZ6	—	0.959	Q5BJZ6 →
Q6NYU2	—	0.959	Q6NYU2 →
Q80YV4	—	0.959	Q80YV4 →
A0FKG7	—	0.958	A0FKG7 →
F1N9S8	—	0.957	F1N9S8 →
Q6PZ05	—	0.956	Q6PZ05 →
HELZ	Probable helicase with zinc finger domain	0.955	landscape →
Q6DFV5	—	0.955	Q6DFV5 →
Q8VDG3	—	0.954	Q8VDG3 →
Q96DT6	—	0.954	Q96DT6 →
Q0IIH8	—	0.954	Q0IIH8 →
Q9Y6W3	—	0.953	Q9Y6W3 →
A6H7H7	—	0.952	A6H7H7 →
D2XV59	—	0.952	D2XV59 →
Q923S8	—	0.952	Q923S8 →
Q9CV28	—	0.952	Q9CV28 →
PARN	Poly(A)-specific ribonuclease PARN	0.952	landscape →
Q9Y2V0	—	0.952	Q9Y2V0 →
Q4A1L5	—	0.951	Q4A1L5 →
Q96RR1	—	0.951	Q96RR1 →
AASDHPPT	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.951	landscape →
Q9UK99	—	0.951	Q9UK99 →