Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 13/20 | 1.00 |
| ▸ | RPS6KA2 | Q15349 | 9/20 | 1.00 |
| ▸ | MAPKAPK2 | P49137 | 7/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12598242 | 0.96 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2MAPKAPK2 | |
| SCHEMBL12598950 | 0.90 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2MAPKAPK2 | |
| SCHEMBL14892574 | 0.89 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2MAPKAPK2 | |
| SCHEMBL12598243 | 0.84 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2MAPKAPK2 | |
| SCHEMBL3079464 | 0.81 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2MAPKAPK2 | |
| SCHEMBL14891718 | 0.81 | RPS6KA2 (1.00) | RPS6KA3RPS6KA2 | |
| SCHEMBL14892139 | 0.81 | RPS6KA2 (1.00) | RPS6KA3RPS6KA2 | |
| SCHEMBL12598631 | 0.79 | RPS6KA2 (1.00) | RPS6KA3RPS6KA2 | |
| SCHEMBL1993378 | 0.79 | RPS6KA2 (0.64) | RPS6KA3RPS6KA2 | |
| SCHEMBL12598195 | 0.79 | RPS6KA3 (1.00) | RPS6KA3RPS6KA2MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150577-B2 | Heterocyclic compounds containing an indole core | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-9150577-B2 | Heterocyclic compounds containing an indole core | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-9150577-B2 | Heterocyclic compounds containing an indole core | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-10-06 | — | — | US | disclosed |
| US-20130109679-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| US-20130109679-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| US-20130109679-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| WO-2011071716-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109679-A1 | HETEROCYCLIC COMPOUNDS CONTAINING AN INDOLE CORE | BRSK2, RPS6KA2, RPS6KB2 | RPS6KA3 4/4885RPS6KA2 2/4885MAPKAPK2 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.